Research Papers

• Mlotkowski, A. J.; Schlegel, H. B.; Chow, C. S. “Calculations of pKa Values for a Series of Aza- and Deaza-Modified Nucleobases”, J. Phys. Chem. A 2023, 127(15), 3526–3534; https://doi.org/10.1021/acs.jpca.3c01358
• Jones, E. L.; Mlotkowski, A. J.; Hebert, S. P.; Schlegel, H. B.; Chow, C. S. “Calculations of pKa Values for a Series of Naturally Occurring Modified Nucleobases”, J. Phys. Chem. A 2022, 126(9), 1518-1529; https://doi.org/10.1021/acs.jpca.1c10905
• He, C. C.; Hamlow, L. A.; Kimutai, B.; Roy, H. A.; Devereaux, Z. J.; Cunningham, N. A.; Martens, J.; Berden, G.; Oomens, J.; Chow, C. S.; Rodgers, M. T. “Structural Determination of Arginine-Linked Cisplatin Complexes via IRMPD Action Spectroscopy: Arginine Binds to Platinum via NO- Binding Mode”, PhysChemChemPhys 2021, 23, 21959–21971.
• Sonousi, A.; Quirke, J. C. L.; Waduge, P.; Janusic, T.; Gysin, M.; Haldimann, K.; Xu, S.; Hobbie, S. N.; Sha, S. H.; Schacht, J.; Chow, C. S.; Vasella, A.; Böttger, E. C.; Crich, D. “An Advanced Apralog with Increased in Vitro and in Vivo Activity Toward Gram-negative Pathogens and Reduced ex Vivo Cochleotoxicity”, ChemMedChem 2021, 16, 335–339.
• Muthunayake, N. S.; Islam, R.; Inutan, E. D.; Colangelo, W.; Trimpin, S.; Cunningham, P. R.; Chow, C. S. “Expression and in Vivo Characterization of the Antimicrobial Peptide Oncocin and Variants Binding to Ribosomes”, Biochemistry 2020, 59, 3380–3391.
• Waduge, P.; Sati, G. C.; Crich, D.; Chow, C. S. “Use of a Fluorescence Assay to Determine Relative Affinities of Semisynthetic Aminoglycosides to Small RNAs Representing Bacterial and Mitochondrial A Sites”, Bioorg. Med. Chem. 2019, 27, 115121.
• Kimutai, B.; He, C. C.; Roberts, A.; Jones, M. L.; Bao, X.; Jiang, J.; Yang, Z.; Rodgers, M. T.; Chow, C. S. “Amino Acid-Linked Platinum(II) Compounds: Non-canonical Nucleoside Preferences and Influence on Glycosidic Bond Stabilities”, J. Biol. Inorg. Chem. 2019, 24, 985–997.
• Matsushita, T.; Sati, G. C.; Kondasinghe, N.; Pirrone, M. G.; Kato, T.; Waduge, P.; Kumar, H.S.; Sanchon, A. C.; Dobosz-Bartoszek, M.; Shcherbakov, D.; Juhas, M.; Hobbie, S. N.; Schrepfer, T.; Chow, C. S.; Polikanov, Y. S.; Schacht, J.; Vasella, A.; Böttger, E. C.; Crich, D. “Design, Multigram Synthesis, and In Vitro and In Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens”, J. Am. Chem. Soc. 2019, 141, 5051–5061.
• Dremann, D. N.; Chow, C. S. “The Use of Electrospray Ionization to Monitor RNA-Ligand Interactions”, Methods Enzymol. 2019, 623, 315–337.
• Waduge, P.; Sakakibara, Y.; Chow, C. S. “Chemical Probing for Examining the Structure of Modified RNAs and Ligands to RNA”, Methods 2019, 156, 110–120.
• Kekulandara, D. N.; Nagi, S.; Seo, H.; Chow, C. S.; Ahn, Y. H. “Redox-Active Peptide Disrupting Trx1-Ask1 Interaction for Selective Activation of Stress Signaling”, Biochemistry 2018, 57, 772–780.
• Sakakibara, Y.; Chow, C. S. “Pseudouridine Modifications Influence Binding of Aminoglycosides to Helix 69 of Bacterial Ribosomes”, Org. Biomol. Chem. 2017, 15, 8535–8543.
• Dremann, D. N.; Chow, C. S. “The Development of Peptide Ligands that Target Helix 69 rRNA of Bacterial Ribosomes”, Bioorg. Med. Chem. 2016, 24, 4486–4491.
• He, C. C.; Kimutai, B.; Bao, X.; Hamlow, L.; Zhu, Y.; Strobehn, S. F.; Gao, J.; Berden, G.; Oomens, J.; Chow, C. S., Rodgers, M. T. “Evaluation of Hybrid Theoretical Approaches for Structural Determination of a Glycine-Linked Cisplatin Derivative via IRMPD Action Spectroscopy”, J. Phys. Chem. A. 2015, 119, 10980–10987.
• Dedduwa-Mudalige, G. N. P.; Chow, C. S. “Cisplatin Targeting of Bacterial Ribosomal RNA Hairpins”, Int. J. Mol. Sci. 2015, 16, 21392–21409.
• Jiang, J.; Kharel, D. N.; Chow, C. S. “Modulation of Conformational Changes in Helix 69 Mutants by Pseudouridine Modifications”, Biophys. Chem. 2015, 200-201, 48–55.
• Jiang, J.; Aduri, R.; Chow, C. S.; SantaLucia, J., Jr. “Structure Modulation of Helix 69 from Escherichia coli 23S Ribosomal RNA by Pseudouridylations”, Nucleic Acids Res. 2014, 42, 3971–3981.
• Rijal, K.; Bao, X.; Chow, C. S. “Amino Acid-Linked Platinum(II) Analogues Have Altered Specificity for RNA Compared to Cisplatin”, Chem. Comm. 2014, 50, 3918–3920.
• Mahto, S. K.; Chow, C. S. “Probing the Stabilizing Effects of Modified Nucleotides in the Bacterial Decoding Region of 16S Ribosomal RNA”, Bioorg. Med. Chem. 2013, 21, 2720–2726.
• Kaur, M.; Rupasinghe, C. N.; Klosi, E.; Spaller, M. R.; Chow, C. S. “Selection of Heptapeptides That Bind Helix 69 of Bacterial 23S Ribosomal RNA”, Bioorg. Med. Chem. 2013, 21, 1240–1247.
• Sakakibara, Y.; Abeysirigunawardena, S.C.; Duc, A.-C.; Dremann, D. N.; Chow, C. S. “Ligand- and pH-Induced Conformational Changes of RNA Domain Helix 69 Reealed by 2-Aminopurine Fluorescence”, Angew. Chem. Int. Ed. Engl. 2012, 51, 12095–12098.
• Sakakibara, Y.; Chow, C. S. “Role of Pseudouridine in Structural Rearrangements of Helix 69 During Bacterial Ribosome Assembly”, ACS Chem. Biol. 2012, 7, 871–878.
• Sumita, M.; Jiang, J.; SantaLucia, J., Jr.; Chow, C. S. “Comparison of Solution Conformations and Stabilities of Modified Helix 69 rRNA Analogues from Bacteria and Human”, Biopolymers 2012, 97, 94–106.
• Kobitski, A. Y.; Hengesbach, M.; Seidu-Larry, S.; Dammertz, K.; Chow, C. S.; van Aershot, A.; Nienhaus, G. U.; Helm, M. “Single-Molecule FRET Reveals a Cooperative Effect of Two Methyl Group Modifications in the Folding of Human Mitochondrial tRNA^Lys“, Chem. Biol. 2011, 18, 928–936.
• Sakakibara, Y.; Chow, C. S. “Probing Conformational States of Modified Helix 69 in 50S Ribosomes”, J. Am. Chem. Soc. 2011, 133, 8396–8399.
• Lamichhane, T. N.; Abeydeera, N. D.; Duc, A.-C.; Cunningham, P. R.; Chow, C. S. “Selection of Peptides Targeting Helix 31 of Bacterial 16S Ribosomal RNA by Screening M13 Phage-Display Libraries”, Molecules 2011, 16, 1211–1239.
• Asare-Okai, P. N.; Chow, C. S. “A Modified Fluorescent Intercalator Displacement Assay for RNA Ligand Discovery”, Anal. Biochem. 2011, 408, 269­–276.
• Li, M.; Duc, A.-C. E.; Klosi, E.; Pattabiraman, S.; Spaller, M. R.; Chow, C. S. “Selection of Peptides that Target the Aminoacyl-tRNA Site of Bacterial 16S Ribosomal RNA”, Biochemistry 2009, 48, 8299–8311.
• Abeydeera, N. D.; Chow, C. S. “Synthesis and Characterization of Modified Nucleotides in the 970 Hairpin Lop of Escherichia coli 16S Ribosomal RNA”, Bioorg. Med. Chem. 2009, 17, 5887–5893.
• Rijal, K.; Chow, C. S. “A New Role for Cisplatin: Probing Ribosomal RNA Structure”, Chem. Comm. 2009, 107–109.
• Li, M.; Shen, J.; Liu, X.; Shao, J.; Yi, W.; Chow, C. S.; Wang, P. G. “Identification of a New a1,2-Fucosyltransferase Involved in O-Antigen Biosynthesis of Escherichia coli O86:B7 and Formation of H-Type 3 Blood Group Antigen”, Biochemistry 2008, 47, 11590–11597. 
Mahto, S. K.; Chow, C. S. “Synthesis and Solution Conformation Studies of the Modified Nucleoside N⁴,2′-O-dimethylcytidine (m⁴Cm) and Its Analogues”, Biooorg. Med. Chem. 2008, 16, 8795–8800.
• Desaulniers, J.-P.; Chang, Y.-C.; Aduri, R.; Abeysirigunawardena, S. C.; SantaLucia, J., Jr.; Chow, C. S. “Pseudouridines in rRNA Helix 69 Play a Role in Loop Stacking Interactions”, Org. Biomol. Chem. 2008, 6, 3892–3895.
• Saraiya, A. A.; Lamichhane, T.  N.; Chow, C. S.; SantaLucia, J., Jr.; Cunningham, P. R. “Identification and Role of Functionally Important Motifs in the 970 Loop of Escherichia coli 16S Ribosomal RNA”, J. Mol. Biol. 2008, 376, 645–657.
• Li, M.; Liu, X.-W., Shao, J.; Shen, J.; Jia, Q.; Yi, W.; Woodward, R.; Chow, C. S.; Wang, P. G. “Characterization of a Novel a-1,2-Fucosyltransferase of Escherichia coli O128:B12 and Functional Investigation of its Common Motif”, Biochemistry 2008, 47, 378–387.
• Abeysirigunawardena, S. C.; Chow, C. S. “pH-Dependent Structural Changes of Helix 69 from Escherichia coli 23S Ribosomal RNA”, RNA 2008, 14, 782–792.
• Chang, Y.-C.; Herath, J.; Wang, T. H.-H.; Chow, C. S. “Synthesis and Solution Conformation Studies of 3-Substituted Uridine and Pseudouridine Derivatives” Bioorg. Med. Chem. 2008, 16, 2676–2686.
• Chao, P-.W.; Chow, C. S. ” Monitoring Aminoglycoside-Induced Conformational Changes in 16S rRNA through Acrylamide Quenching”, Bioorg. Med. Chem. 2007, 15, 3825–3831.
• Hägerlöf, M.; Papsai, P.; Chow, C. S.; Elmroth, S. K. C. “More Pronounced Salt Dependence and Higher Reactivity for Platination of the Hairpin r(CGCGUUGUUCGCG) Compared with d(CGCGTTGTTCGCG)”, J. Biol. Inorg. Chem. 2006, 11, 974–990.
• Kieltyka, J. W.; Chow, C. S. “Probing RNA Hairpins with Cobalt(III)hexammine and Electrospray Ionization Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 2006, 17, 1376–1382.
• Desaulniers, J.-P.; Chui, H. M.-P.; Chow, C. S. “Solution Conformations of Two Naturally Occurring RNA Nucleosides: 3-Methyluridine and 3-Methylpseudouridine”, Bioorg. Med. Chem. 2005, 13, 6777–6781.
• Sumita, M.; Desaulniers, J.-P.; Chang, Y.-C.; Chui, H. M.-P.; Clos, L., II; Chow, C. S. “Effects of Nucleotide Substitution and Modification on the Stability and Structure of Helix 69 From 28S rRNA”, RNA 2005, 11, 1420–1429.
• Hamdy, N.; Goustin, A. S.; Chow, C. S.; Desaulniers, J.-P.; Al-Katib, A. “Sheep Red Blood Cells Armed with Anti-CD20 Single Chain Variable Fragments (scFvs) Fused to a Glycosylphosphatidylinositol (GPI) Anchor: A Strategy to Target CD20-Positive Tumor Cells”, J. Immun. Methods 2005,  297, 109–124.
• Esho, N.; Desaulniers, J.-P.; Davies, B.; Chui, H. M.-P.; Rao, M. S.; Chow, C. S.; Szafert, S.; Dembinski, R. “NMR Conformational Analysis of p-Tolyl Furanopyrimidine 2′-Deoxyribonucleoside and Crystal Structure of its 3′,5′-Di-O-acetyl Derivative”,  Bioorg. Med. Chem. 2005, 13, 1231–1238.
• Desaulniers, J.-P.; Ksebati, B.; Chow, C. S. “Synthesis of ¹⁵N-Enriched Pseudouridine Derivatives”, Org. Lett. 2003, 5, 4093–4096.
• Chui, H. M.-P.; Desaulniers, J.-P.; Scaringe, S. A.; Chow, C. S. “Synthesis of Helix 69 of E. coli 23S rRNA Containing its Natural Modified Nucleosides, m³Psi and Psi”, J. Org. Chem. 2002, 67, 8847­–8854.
• Liu, M.; Amro, N. A.; Chow, C. S.; Liu, G.-Y. “Production of Nanostructures of DNA on Surfaces”, Nanolett. 2002, 2, 863–867.
• Chow, C. S.; Cunningham, P. R.; Lee, K.-S.; Meroueh, M.; SantaLucia, J., Jr.; Varma, S. “Photoinduced Cleavage by a Rhodium Complex at G-U Mismatches and Exposed Guanines in Large and Small RNAs”, Biochimie 2002, 84, 859–868.
• Mohammad, R.; Abubakr, Y.; Dan, M.; Aboukameel, A.; Chow, C.; Mohamed, A.; Hamdy, N.; Al-Katib, A. “Bcl-2 Antisense Oligonucleotides are Effective Against Systemic but not CNS Disease in SCID Mice Bearing Human t(14;18) Follicular Lymphoma”, Clin. Cancer Res. 2002, 8, 1277–1283.
• Llano-Sotelo, B.; Azucena, E. F., Jr.; Kotra, L. P.; Mobashery, S.; Chow, C. S. “Aminoglycosides Modified by Resistance Enzymes Display Diminished Binding to the Bacterial Ribosomal Acyl-Transfer Site”, Chem. Biol. 2002, 9, 455–463.
• Haddad, J.; Kotra, L. P.; Llano-Sotelo, B.; Kim, C.; Azucena, E. F., Jr. ; Liu, M.; Vakulenko, S. B.; Lee, H.; Chow, C. S.; Mobashery, S. “Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site”, J. Am. Chem. Soc. 2002, 124, 3229–3237.
• Chui, H. M.-P.; Meroueh, M.; Scaringe, S. A.; Chow, C. S. “Probing the Structural Role of the N3 Methyl Group of a Pseudouridine Derivative Found in Escherichia coli 23S Ribosomal RNA”, Bioorg. Med. Chem. 2002, 10, 325–332.
• Meroueh, M.; Grohar, P. J.; Qiu, J.; SantaLucia, J., Jr.; Scaringe, S. A.; Chow, C. S. “Unique Structural and Stabilizing Roles for the Individual Pseudouridine Residues in the 1920 Region of Escherichia coli 23S rRNA”, Nucleic Acids Res. 2000, 28, 2075–2083.
• Meroueh, M.;  Kjellström, J.; Mårtensson, K. S. M.; Elmroth, S. K. C.; Chow, C. S. “Reactions of Platinum(II) Complexes with a DNA Hairpin, d(CGCGTTGTTCGCG): Structural Characterization and Kinetic Studies”, Inorg. Chim. Acta 2000, 297, 145–155.
• Grohar, P. J.; Chow, C. S. “A Practical Synthesis of the Common Modified RNA Nucleoside Pseudouridine”, Tet. Lett. 1999, 40, 2049–2052.
• Meroueh, M.; Chow, C. S. “Thermodynamics of RNA Hairpins Containing Single Internal Mismatches”, Nucleic Acids Res. 1999, 27, 1118–1125.
• Llano-Sotelo, B.; Chow, C. S. “RNA-Aminoglycoside Antibiotic Interactions: Fluorescence Detection of Binding and Conformational Change”, Bioorg. Med. Chem. Lett. 1999, 9, 213–216.
• Bogdan, F. M.; Chow, C. S. “The Synthesis of Allyl- and Allyloxycarbonyl-Protected RNA Phosphoramidites.  Useful Reagents for Solid-Phase Synthesis of RNAs with Base-Labile Modifications”, Tet. Lett. 1998, 39, 1897–1900.

Reviews

• Jiang, J.; Seo, H.; Chow, C. S. “Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions”, Acc. Chem. Res. 2016, 49, 893–901.
• Jiang, J.; Sakakibara, Y.; Chow, C. S. “Helix 69: A Multitasking RNA Motif as a Novel Drug Target”, Isr. J. Chem. 2013, 53, 379–390.
• Abeydeera, N. D.; Chow, C. S. “Modified Nucleosides in RNA” in Wiley Encyclopedia of Chemical Biology 2008, John Wiley & Sons, Inc. (Ed. T. P. Begley), pp. 1-14.
• Chow, C. S.; Mahto, S. K.; Lamichhane, T. N. “Combined Approaches to Site-Specific Modification of RNA”, ACS Chem. Biol. 2008, 3, 30–37.
• Chow, C. S.; Lamichhane, T. N.; Mahto, S. K. ” Expanding the Nucleotide Repertoire in the Ribosome with Post-transcriptional Modifications”, ACS Chem. Biol. 2007, 2, 610–619.
• Kling, D.; Chow, C. S.; Mobashery, S. “Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosomes” in Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery 2007, John Wiley & Sons, Inc. (Ed. D. P. Arya), pp. 225–233.
• Chow, C. S.; Bogdan, F. M. “A Structural Basis for RNA-Ligand Interactions”, Chem. Rev. 1997, 97, 1489–1513.

Other

• Chow, C. (2008, August 14). Site-specifically modified ribosomal RNAs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks

Education

• Mathur, A.; Hwalek, M.; Straub, V.; Chow, C.S. “Increasing Faculty Support, Respect, and Ability to Help Doctoral Students Explore Non-Academic Research Career Opportunities”, Heliyon 2023, 9(1), e13052.
• Brandt, P. D. et al. “A Cross-Institutional Analysis of the Effects of Broadening Trainee Professional Development on Research Productivity”, PLoS Biol. 2021, 19(7), e3000956.
• Mathur, A.; Chow, C. S.; Feig. A. L.; Kenaga, H.; Moldenhauer, J. A.; Muthunayake, N. S.; Ouellett, M. L.; Pence, L. E.; Straub. V. “Exposure to Multiple Career Pathways by Biomedical Doctoral Students at a Public Research University”, PLoS ONE 2018, 13(6), e0199720.
• Hitchcock, P. et al. “Point of View: The Future of Graduate and Postdoctoral Training in the Biosciences”, eLife 2017, 6, e32715.
• Chow, C. S.; Somne, S. “Synthesis and Purification of a Hammerhead Ribozyme and a Fluorescein-Labeled RNA Substrate.  A Biochemistry Laboratory: Part 1”, J. Chem. Ed. 1999, 76, 648.
• Chow, C. S.; Somne, S.; Llano-Sotelo, B. “Monitoring Hammerhead Ribozyme Catalyzed Cleavage with a Fluorescein-Labeled Substrate; Effects of Magnesium Ions and Antibiotic Inhibitors. A Biochemistry Laboratory: Part 2”, J. Chem. Ed. 1999, 76, 651.

Funding

• Our work was supported previously by a Schaap Faculty Scholar Award, the National Institutes of Health (DP7 OD018427 through 8/2019, Mathur and Chow), and the National Science Foundation (CHE 1904754, Bryant-Friedrich). Current funding includes IMSD at Wayne State University graduate training program (T32GM139807, 2/2021–present) and Chemistry Biology Interface training program (T32GM142519, 7/2021–present).