Dr. Karen Marrero discusses the indigenous societies in the Americas prior to the arrival of Europeans. Dr. Marrero describes how following the arrival of the Europeans, indigenous communities were suffered from the diseases Europeans brought with them including smallpox, measles, and influenza beginning in the 1400s. These diseases spread throughout indigenous communities during the next few centuries killing thousands.
Link to presentation: Smallpox and Epidemics Among Indigenous People of North America

Image credit: Image of 16th century Aztec drawing of smallpox victims. Courtesy of Wiki Commons. The image is in the public domain.