Publications

Click here for a list of NCBI publications

Soukar I, Mitra A, Pile LA. 2023. Analysis of the chromatin landscape and RNA polymerase II binding at SIN3-regulated genes. Biology Open.12(11). doi: 10.1242/bio.060026

Soukar I, Amarasinghe A, Pile LA. 2023. Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex. The Enzymes. 28(53):33-68. doi: 10.1016/bs.enz.2023.06.001

Mitra A, Vo L, Soukar I, Chaubal A, Greenberg ML, Pile LA. 2022. Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival. Biochim Biophys Acta, Mol Cell Res. 1869(10):119322. doi: 10.1016/j.bbamcr.2022.119322

Dwyer K, Agarwal N, Pile L, Ansari A. 2021. Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription. Front Mol Biosci. 8:669004. doi: 10.3389/fmolb.2021.669004.

Mitra A, Raicu AM, Hickey SL, Pile LA and Arnosti DN. 2021. Soft repression: Subtle transcriptional regulation with global impact. Bioessays. 43(2):e2000231. doi: 10.1002/bies.202000231.

Liu M, Saha N, Gajan A, Saadat N, Gupta SV and Pile LA. 2020. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription. J Biol Chem. 295, 375-389. doi: 10.1074/jbc.RA119.010032.

Barnes VL, Laity KA, Pilecki M, and Pile LA. 2018. Systematic Analysis of SIN3 Histone Modifying Complex Components During Development. Sci Rep. 8(1):17048. doi: 10.1038/s41598-018-35093-0.

Chaubal A and Pile LA. 2018. Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms. Epigenetics & Chromatin. 11(1):17. doi: 10.1186/s13072-018-0188-y.

Liu M and Pile LA. 2017. The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism. J Biol Chem. 292(5):1970-1976. doi: 10.1074/jbc.M116.749754.

Chaubal A, Todi SV, and Pile LA. 2016. Inter-isoform-dependent Regulation of the Drosophila Master Transcriptional Regulator SIN3. J Biol Chem. May 27;291(22):11566-71. doi: 10.1074/jbc.C116.724799.

Saha N, Liu M, Gajan A, and Pile LA. 2016. Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms. BMC Genomics. 17(1):111. doi: 10.1186/s12864-016-2428-5.

Gajan A, Barnes VL, Liu M, Saha N and Pile LA. 2016. The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Epigenetics & Chromatin 9:4. doi: 10.1186/s13072-016-0053-9.

Liu M, Barnes VL and Pile LA. 2015. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. G3 (Bethesda). 6(1):121-32. doi: 10.1534/g3.115.024273.

Holowatyj A, Yang ZQ and Pile LA. 2015. Histone lysine demethylases in Drosophila melanogaster. Fly (Austin). 9(1):36-44. doi: 10.1080/19336934.2015.1074787.

Barnes VL, Bhat A, Unnikrishnan A, Heydari AR, Arking R, and Pile LA. 2014. SIN3 is critical for stress resistance and modulates lifespan. Aging 6(8).

Swaminathan A, Barnes VL, Fox S, Gammouh S and Pile LA. 2012. Identification of Genetic Suppressors of the Sin3A Knockdown Wing Phenotype. PLoS One 7(11):e49563.

Spain MM, Caruso JA, Swaminathan A, and Pile LA. 2010. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem. 285(35):27457-67.

Barnes VL, Strunk BS, Lee I, Hüttemann M, and Pile LA. 2010. Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function. BMC Biochemistry. 11:26.

Swaminathan A and Pile LA. 2010. Regulation of cell proliferation and wing development by Drosophila SIN3 and String. Mech Dev. 127:96-106.

Sharma V, Swaminathan A, Bao R, and Pile LA. 2008. Drosophila SIN3 is required at multiple stages of development. Dev Dyn. 237:3040-3050.

Pile LA, Spellman PT, Katzenberger RJ, and Wassarman DA. 2003. The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: Implications for the regulation of energy metabolism. J Biol Chem. 278:37840-8.

Pile LA, Schlag EM, and Wassarman DA. 2002. The SIN3/RPD3 deacetylase complex is essential for G2 phase cell cycle progression and stability of the SMRTER corepressor. Mol. Cell. Biol. 22:4965-4976.

Pile LA and Wassarman DA. 2002. Localizing transcription factors on chromatin by immunofluorescence. Methods. 26:3-9.

Pile LA, Lee FW-H and Wassarman DA. 2001. The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. Cell Mol Life Sci. 58:1715-1718.

Ballestar E, Pile LA, Wassarman DA, Wolffe AP and Wade PA. 2001. A Drosophila MBD family member is a transcriptional corepressor associated with specific genes. Eur J Biochem. 268:5397-5406.

Pile LA and Wassarman DA. 2000. Chromosomal localization links the SIN3/RPD3 complex to the regulation of chromatin condensation, histone acetylation, and gene expression. EMBO J. 19:6131-6140.

Wassarman DA, Aoyagi N, Pile LA, and Schlag EM. 2000. TAF250 is required for multiple developmental events in Drosophila. Proc Natl Acad Sci U S A. 97:1154-1159.

Pile LA and Cartwright IL. 2000. GAGA factor-dependent transcription and establishment of DNase hypersensitivity are independent and unrelated events in vivo. J Biol Chem. 275:1398-1404.