2023
60. Gupta, S.; Chapman, K.; Praneeth, S.; Stemmer, P. M.; Allen, M. J.; Dittrich, T. M.; Kodanko, J. J., Semi-synthetic proteins as metal ion capture agents: Catch and release of Ni(II) and Cu(II) with myoglobin bioconjugates. ACS Sustain. Chem. Eng. 2023 (In Press).
59. Denison, M.; Ahrens, J. J.; Dunbar, M. N.; Warmahaye, H.; Majeed, A.; Turro, C.; Kocarek, T. A.; Sevrioukova, I. F.; Kodanko, J. J., Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4. Inorg. Chem. 2023, 62 (7), 3305-3320.
2022
58. Gupta, S.; Ward, C. L.; Perera, S. S.; Gowan, C. T.; Dittrich, T. M.; Allen, M. J.; McElmurry, S. P; Kodanko, J. J., Development of a Highly Selective Ni(II) Chelator in Aqueous Solution. Inorg. Chem. 2022, 61 (48), 19492-19051.
57. Cruché, C.; Gupta, S.; Kodanko, J.; Collins, S. K., Heteroleptic Copper (I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications. Molecules 2022, 27 (12), 3745.
56. Denison, M.; Steinke, S. J.; Majeed, A.; Turro, C.; Kocarek, T. A.; Sevrioukova, I. F.; Kodanko, J. J., Ir (III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy. Inorg. Chem. 2022, 61 (35), 13673-13677.
55. Toupin, N.; Herroon, M. K.; Thummel, R. P.; Turro, C.; Podgorski, I.; Gibson, H.; Kodanko, J. J., Metalloimmunotherapy with Rhodium and Ruthenium Complexes: Targeting Tumor‐Associated Macrophages. Chem. Eur. J. 2022, 28 (24), e202104430.
54. Toupin, N. P., Steinke, S., Herroon, M., Podgorski, I., Turro, C., Kodanko, J. J. Unlocking the Potential of Ru(II) Dual-Action Compounds with the Power of the Heavy Atom Effect. Photochem. Photobiol. 2022, 98, 378.
53. Steinke, S. J.; Gupta, S.; Piechota, E. J.; Moore, C. E.; Kodanko, J. J.; Turro, C., Photocytotoxicity and photoinduced phosphine ligand exchange in a Ru(II) polypyridyl complex. Chem. Sci. 2022, 13, 1933.
2021
52. Gupta, S.; Vandevord, J. M.; Loftus, L. M.; Toupin, N.; Al-Afyouni, M. H.; Rohrabaugh, T. N., Jr.; Turro,C.; Kodanko, J. J. Ru(II)-Based Acetylacetonate Complexes Induce Apoptosis Selectively in Cancer Cells. Inorg. Chem. 2021, 60, 18964.
51. Lanquist, A. P.; Gupta, S.; Al-Afyouni, K. F.; Al-Afyouni, M.; Kodanko, J. J.; Turro, C., Trifluoromethyl substitution enhances photoinduced activity against breast cancer cells but reduces ligand exchange in Ru (ii) complex. Chem. Sci. 2021, 12 (36), 12056-12067
50. Toupin, N.; Steinke, S. J.; Nadella, S.; Li, A.; Rohrabaugh Jr, T. N.; Samuels, E. R.; Turro, C.; Sevrioukova, I. F.; Kodanko, J. J., Photosensitive Ru (II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4. J. Am. Chem. Soc. 2021, 143 (24), 9191-9205.
2020
49. Toupin, N. P.; Nadella, S.; Steinke, S. J.; Turro, C.; Kodanko, J. J., Dual-Action Ru (II) Complexes with Bulky π-Expansive Ligands: Phototoxicity without DNA Intercalation. Inorg. Chem. 2020, 59 (6), 3919-3933.
2019
48. Toupin, N. P.; Arora, K.; Shrestha, P.; Peterson, J. A.; Fischer, L. J.; Rajagurubandara, E.; Podgorski, I.; Winter, A. H.; Kodanko, J. J., BODIPY-caged photoactivated inhibitors of cathepsin B flip the light switch on cancer cell apoptosis. ACS Chem. Biol. 2019, 14 (12), 2833-2840.
2018
47. Arora, K., Herroon, M., Al-Afyouni, M. H., Toupin, N. P., Rohrabaugh, T. N., Loftus, L. M., Podgorski, I., Turro, C., Kodanko, J. J. Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers. J. Am. Chem. Soc. 2018, 140, 14367.
46. Rohrabaugh, T. N., Jr., Rohrabaugh, A. M., Kodanko, J. J., White, J. K., Turro, C. Photoactivation of imatinib-antibody conjugate using low-energy visible light from Ru(II)-polypyridyl cages. Chem. Commun. 2018, 54, 5193.
45. Rohrabaugh, T. N., Jr., Collins, K. A., Xue, C., White, J. K., Kodanko, J. J., Turro, C. New Ru(II) complex for dual photochemotherapy: release of cathepsin K inhibitor and 1O2 production. Dalton Trans. 2018, 47, 11851.
44. Li, A., Turro, C., Kodanko, J. J. Ru(II) Polypyridyl Complexes Derived from Tetradentate Ancillary Ligands for Effective Photocaging. Acc. Chem. Res. 2018, 51, 1415.
43. Huisman, M., Kodanko, J., Arora, K., Herroon, M. K., Alnaed, M., Endicott, J. F., Podgorski, I., Kodanko, J. J. Affinity Enhanced Luminescent Re(I)- and Ru(II)-Based Inhibitors of the Cysteine Protease Cathepsin L. Inorg. Chem. 2018, 57, 7881.
42. Li, A.; Turro, C., Kodanko, J, J., Ru(II) polypyridyl complexes as photocages for bioactive compounds containing nitriles and aromatic heterocycles. Chem. Commun. 2018, 53, 3673-3676. [DOI: 10.1039/C7CC09000E]
41. Nisbett, K., Tu, Y.-J., Turro, C., Kodanko, J. J., Schlegel, H. B. DFT Investigation of Ligand Photodissociation in [RuII(tpy)(bpy)(py)]2+ and [RuII(tpy)(Me2bpy)(py)]2+ Complexes. Inorg. Chem. 2018,
57, 231.
2017
40. Loftus, L. M.; Li, A.; Fillman, K. L.; Martin, P. D.; Kodanko, J. J.; Turro, C., Unusual role of excited state mixing in the enhancement of photoinduced ligand exchange in Ru(II) complexes. J. Am. Chem. Soc. 2017, 139(50), 18295-18306. [DOI: 10.1021/jacs.7b09937]
39. Li, A.; Yadav, R.; White, J. K.; Herroon M. K.; Callahan, B. P.; Podgorski, I.; Turro, C.; Kodanko J. J., Illuminating cytochrome P450 binding: Ru(II)-caged inhibitors of CYP17A1. Chem. Commun. 2017, 53, 3673-3676. [DOI: 10.1039/C7CC01459G]
2016
38. Huisman, M.; White, J. K.; Lewalski, G. V.; Podgorski, I.; Turro, C.; Kodanko J. J., Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chem. Commun. 2016, 52, 12590-12593. [DOI: 10.1039/C6CC07083C]
37. Arora, K.; White, J. K.; Sharma, R.; Mazumder, S.; Martin, P. D.; Schlegel, H. B.; Turro, C.; Kodanko, J. J., Effects of methyl substitution in ruthenium tris(2-pyridylmethyl)amine photocaging groups for nitriles. Inorg. Chem. 2016, 55(14), 6968-6979. [DOI: 10.1021/acs.inorgchem.6b00650]
36. Herroon M. K.; Sharma, R.; Rajagurubandara, E.; Turro, C.; Kodanko Jeremy, J. J.; Podgorski, I., Photoactivated inhibiton of cathepsin K in a 3D tumor model. Biol. Chem. 2016, 397, 571. [DOI: 10.1515/hsz-2015-0274]
35. Loftus, L. M.; White, J. K.; Albani, B. A.; Kohler, L.; Kodanko, J. J.;
Thummel, R. P.; Dunbar, K. R.; Turro, C., New Ru(II) complex for dual activity: photoinduced ligand release and singlet oxygen production. Chem. Eur. J. 2016, 22, 3704-3708. [DOI: 10.1002/chem.201504800]
34. Li, A.; White, J. K.; Arora, K.; Herroon, M. K.; Martin, P. D.; Schlegel, H. B.; Podgorski, I.; Turro, C.; Kodanko, J. J., Selective release of aromatic heterocycles from ruthenium tris(2-pyridylmethyl)amine with visible light. Inorg. Chem. 2016, 55(1), 10-12. [DOI: 10.1021/acs.inorgchem.5b02600]
2015
33. Ramalho, S. D.; Sharma R.; White, J. K.; Aggarwal, N.; Chalasani, A.; Sameni, M.; Moin, K.; Vieira, P. C.; Turro, C.; Kodanko, J. J.; Sloane, B. F., Imaging sites of inhibition of proteolysis in pathomimetic human breast cancer cultures by light-activated ruthenium compound. PLoS One, 2015, 10(11). [DOI: 10.1371/journal.pone.0142527]
32. Tu, Y.; Mazumder, S.; Endicott, J. F.; Turro, C.; Kodanko, J. J.; Schlegel, H. B., Selective photodissociation of acetonitrile ligands in ruthenium polypyridyl complexes studied by density functional theory. Inorg. Chem. 2015, 54, 8003-8011. [DOI: 10.1021/acs.inorgchem.5b01202]
31. Sharma, R.; Knoll, J. D.; Ancona, N.; Martin, P. D.; Turro, C.; Kodanko, J. J., Solid-phase synthesis as a platform for the discovery of new ruthenium complexes for efficient release of photocaged ligands with visible light. Inorg. Chem. 2015, 54, 1901-1911. [DOI: 10.1021/ic502791y]
2014
30. Sharma, R.; Knoll, J. D.; Turro, C.; Podgorski, I.; Kodanko, J. J., Ruthenium tri(2-pyridylmethyl)amine is an effective photocaging group for nitriles. Inorg. Chem. 2014, 53, 3272-3276. [DOI: 10.1021/ic500299s]
29. Respondek, T.; Sharma, R.; Herroon, M. K.; Garner, R. N.; Knoll, J. D.; Cueny, E.; Turro, C.; Podgorski, I.; Kodanko, J. J., Inhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound. ChemMedChem, 2014, 9, 1306-1315. [DOI: 10.1002/cmdc.201400081]
2013
28. Prakash, J.; Kodanko, J. J., Metal-based methods for protein inactivation. Curr. Opin. Chem. Biol. 2013, 17, 197-203. [DOI: 10.1016/j.cbpa.2012.12.011]
2012
27. Zuo, J.; Schmitt, S.; Prakash, J.; Kodanko, J. J.; Dou, Q. P., Novel polypyridyl chelators deplete cellular zinc and destabilize the X-linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells. J. Cell. Biochem. 2012, 113, 2567-2575. [DOI: 10.1002/jcb.24132]
26. Prakash J.; Kodanko J. J., Synthesis, characterization and glutathionylation of cobalamin model complexes [Co(N4PyCO2Me)Cl]Cl2 and [Co(Bn-CDPy3)Cl]Cl2. Inorg. Chem. 2012, 51, 2689-2698. [DOI: 10.1021/ic2026736]
25. Prakash J.; Schmitt S.; Dou Q. P., Kodanko J. J., Inhibition of the purified 20S proteasome by non-heme iron complexes. Metallomics, 2012, 4, 174-178. [DOI: 10.1039/c2mt00131d]
24. Respondek T.; Cueny E.; Kodanko J. J., Cumyl ester as the C-terminal protecting group in the enantioselective alkylation of glycine benzophenone imine. Org. Lett. 2012, 14(1), 150-153. [DOI: 10.1021/ol202939g]
2011
23. Respondek T.; Garner R. N.; Herroon M. K.; Podgorski I.; Turro C.; Kodanko J. J., Light activation of a cysteine protease inhibitor: caging of a peptidomimetic nitrile with Ru (bpy)2. J. Am. Chem. Soc. 2011, 133(43), 17164-17167. [DOI: 10.1021/ja208084s]
22. Jackson C. S.; Schmitt S.; Dou Q. P.; Kodanko J. J., Synthesis, characterization and reactivity of the stable iron carbonyl complex [Fe(CO)(N4Py)](ClO4)2: photoactivated carbon monoxide release, growth inhibitory activity and peptide ligation. Inorg. Chem. 2011, 5(12), 5336-5338. [DOI: 10.1021/ic200676s]
21. Prakash J.; Kodanko J. J., Selective inactivation of serine proteases by nonheme iron complexes. Inorg. Chem. 2011, 50(9), 3934-3945. [DOI: 10.1021/ic102320j]
20. Jabre N. D.; Korostelova N.; Kodanko J. J., A highly divergent approach for synthesis of metal-binding peptide libraries. J. Org. Chem. 2011, 76(7), 2273-2276. [DOI: 10.1021/jo102371q]
2010
19. Abouelatta, A. I.; Sonk, J. A.; Hammoud, M. M.; Zurcher, D. M.; McKamie, J. J.; Schlegel, B. H.; Kodanko, J. J., Synthesis, characterization and theoretical studies of metal complexes derived from the chiral tripyridylamine ligand Bn-CDPy3. Inorg. Chem. 2010, 49(11), 5202-5211. [DOI: 10.1021/ic100322p]
18. Campanali, A. A.; Kwiecien, T. D.; Hryhorczuk, L.; Kodanko, J. J., Oxidation of glutathione by [FeIV(O)(N4Py)]2+: characterization of an [FeIII(SG)(N4Py)]2+ intermediate. Inorg. Chem. 2010, 49(11), 4759-4761. [DOI: 10.1021/ic100439n]
17. Jackson, C. S.; Kodanko, J. J., Iron-binding and mobilization from ferritin by polypyridyl ligands. Metallomics, 2010, 2, 407-411. [DOI: 10.1039/C003414B]
16. Ekkati, A. R.; Campanali, A. A.; Abouelatta, A. I.; Shamoun, M.; Kalapugama, S.; Kelley, M.; Kodanko, J. J., Preparation of N-acetyl, tert-butyl amide derivatives of the twenty natural amino acids. Amino Acids, 2010, 38(3), 747-751. [DOI: 10.1007/s00726-009-0279-y]
15. Jabre, N. D.; Respondek, T.; Ulku, S.; Korostelova N.; Kodanko, J. J., A divergent strategy for attaching polypyridyl ligands to peptides. J. Org. Chem. 2010, 75(3), 650-659. [DOI: 10.1021/jo9021953]
2009
14. Friedle, S.; Kodanko, J. J.; Morys, A. J.; Hayashi T.; Moenne-Loccoz, P.; Lippard, S. J., Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV. J. Am. Chem. Soc. 2009, 131, 14508-14520. [DOI: 10.1021/ja906137y]
13. Jabre, N. D.; Hryhorczuk, L.; Kodanko, J. J., Stability of a ferryl-peptide conjugate is controlled by a remote substituent. Inorg. Chem. 2009, 48, 8078-8080. [DOI: 10.1021/ic9013653]
12. Abouelatta, A. I.; Campanali, A. A.; Ekkati, A. R.; Shamoun, M.; Kalapugama, S.; Kodanko, J. J., Oxidation of the twenty natural amino acids by a ferryl complex: kinetic and mechanistic studies with peptide model compounds. Inorg. Chem. 2009, 48, 7729-7739. [DOI: 10.1021/ic900527c]
2008
11. Friedle, S.; Kodanko, J. J.; Fornace, K. L.; Lippard, S. J., 9-triptycenecarboxylate-bridged diiron(II) complexes: capture of the paddlewheel geometric isomer. J. Mol. Struct. 2008, 890, 317-327. [DOI: 10.1016/j.molstruc.2008.05.030]
10. Hammoud, M. M.; McKamie, J. J.; Heeg, M. J.; Kodanko, J. J., Synthesis of the chiral tripyridyldiamine ligand Bn-CDPy3 and characterization of its Co(III) complex [Co(Bn-CDPy3)Cl]Cl2. Dalton Trans. 2008, 4843-4845. [DOI: 10.1039/B810980J]
9. Kodanko, J. J.; Lippard, S. J., Synthesis and charachterization of a ditriflate-bridged, diiron(II) complex with syn-N-Donor ligands: [Fe2(μ-OTf)2(PIC2DET)2](BARF)2. Inorg. Chem. Acta. 2008, 361, 894. [DOI: 10.1016/j.ica.2007.02.029]
2007
8. Ekkati, A. R.; Kodanko, J. J., Targeting peptides with an iron-based oxidant: cleavage of the amino acid backbone and oxidation of side chains. J. Am. Chem. Soc. 2007, 129, 12390. [DOI: 10.1021/ja075075i]
7. Kodanko, J. J.; Hiebert, S.; Peterson, E. A.; Sung, L.; Overman, L. E.; de Moura Linck, V.; Goerck, G. C.; Amador, T. A.; Leal, M. B.; Elisabetsky, E., Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activity. J. Org. Chem. 2007, 72(21), 7909-7914. [DOI: 10.1021/jo7013643]
2005
6. Kodanko, J. J.; Xu, D.; Lippard, S. J., Iron substitution of sodium in a carboxylate-bridged, heterodinuclear sodium-iron complex. J. Am. Chem. Soc. 2005, 127, 16004. [DOI: 10.1021/ja054943d]
5. Kodanko, J. J.; Morys, A. J.; Lippard, S. J., Synthesis of diethynyltriptycene-linked dipyridyl ligands. Org. Lett. 2005, 7, 45854588. [DOI: 10.1021/ol051700h]
2004
4. Huang, A.; Kodanko, J. J.; Overman, L. E., Asymmetric synthesis of pyrrolidinoindolines. Application for the practical total synthesis of (-)-phenserine. J. Am. Chem. Soc. 2004, 126, 14043. [DOI: 10.1021/ja046690e]
2003
3. Dounay, A.; Hatanaka, K.; Kodanko, J. J.; Oestreich, M.; Overman, L. E.; Pfeifer, L. Weiss, M. M., Catalytic asymmetric synthesis of quaternary carbons bearing two aryl substituents. Enantioselective synthesis of 3-alkyl-3-aryl oxindoles by catalytic asymmetric intramolecular heck reactions. J. Am. Chem. Soc. 2003, 125, 6261. [DOI: 10.1021/ja034525d]
2. Kodanko, J. J.; Overman, L. E., Enantioselective total syntheses of the cyclotryptamine alkaloids hodgkinsine and hodgkinsine B. Angew. Chem. Int. Ed. 2003, 42, 2528. [DOI: 10.1002/anie.200351261]
2001
1. Oestreich, M.; Dennison, P. R.; Kodanko, J. J.; Overman, L. E., Thwarting b-hydride elimination: capture of the alkylpalladium intermediate of an asymmetric intramolecular heck reaction. Angew. Chem. Int. Ed. 2001, 40, 1439. [DOI: 10.1002/1521-3773(20010417)40:8<1439::AID-ANIE1439>3.0.CO;2-F]