Congratulations to Udana Ariyaratne, Valentine Nwanelo, Rachael Tiamiyu, Ishadi Kodikara, and Mary Kay H. Pflum on their latest research article titled “Proteomics-Based Trapping to Study Substrates of Histone Deacetylase 6 Catalytic Domain 1.” Histone deacetylase 6 (HDAC6) is linked with various cellular functions, such as gene expression and protein degradation, as well as many diseases. HDAC6 is also unique among the other 11 metal-dependent HDAC family members due to the presence of two independent and active deacetylase domains (CD1 and CD2). Hence, these studies document the interplay between protein deacetylation and degradation by HDAC6 CD1 and how it influences protein degradation via E3 ligases. You can read further here: Biochemistry. 2025 Jul 1;64(13):2778-2792. doi: 10.1021/acs.biochem.5c00072.