83) Wakpal, J.; Yost-Slinker, D.; Hotor, M.; Nguyen, H. M.* “Systematic Design and Synthesis of 50-Membered Heparan Sulfate Mimetics from Natural Aminoglycosides for Studying Their Interactions with Fibroblast Growth Factor” 2025 (manuscript in preparation).
82) Hotor, M.; Wakpal, J.; Effah, S.; Walker, A.; Nguyen, H. M.* “Could Hydrophobicity of Sulfated Pseudo-Trisaccharides Derived from Repurposing Aminoglycoside Tobramycin Modulate the Enzymatic Activity of Heparanase in Cancer Cells?” 2025 (manuscript in preparation).
81) Singh, K.; Tapayan, A. S.; Sletten, E. T.; Loka, R. S.; Neta, I.; Vlodavsky, I.; Nguyen, H. M. “Evaluation of Heparanase Inhibiting Polymeric Heparan Sulfate Mimetic to Attenuate Myeloma Tumor Growth and Metastasis into Bones and Bone Marrow.” 2025 (manuscript in preparation).
80) Abdulsalam, H.; Hix, M. A.; Philip, L; Singh, K.; Walker, A.;* Nguyen, H. M.* “Structure-Based Discovery of Heparanase Inhibitors from Aminoglycoside Paromomycin.” 2025 (manuscript in preparation).
79) Philip, L.; Abdulsalam, H.; Singh, K.; Nguyen, H. M.* “Investigating Selectivity and Binding Affinity of Branched Pseudo-Tetrasaccharide Aminoglycosides-Based Heparan Sulfate Mimetics toward Heparanase and Platelet Factor 4.” 2025 (manuscript in preparation).
78) Abdulsalam, H.; Philip, L.; Singh, K.; Farhound, M.; Neta, I.; Vlodavsky, I.; Nguyen, H. M.* “Repurposing Paromomycin and Neomycin Aminoglycosides as Heparanase Inhibitors to Attenuate Tumor Growth and Metastasis” 2025 (manuscript in preparation).
77) Li, C.-X.; English, C. K.; Ahiadorme, D. A.; Nguyen, H. M. “Phenanthroline Assisted Stereoselective Synthesis of 2-Deoxy Glycosides.” 2025 (manuscript submitted).
76) Chukwu, F. O.; Arachchi, M. K.; Nguyen, H. M.* “Rhodium-Catalyzed Allylic Amination for the Enantioselective Synthesis of Tertiary β-Fluoroamines” Org. Lett. 2025, 27, 594-599.
75) Zhang, J.; Song, Z.; Singh, K.; Tapayan, A. S.; Wang, K.-W.; Chien, H. T.; Kuo, M.-H.; Zhang, K.; Nguyen, H. M. “Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Endoplasmic Reticulum Stress Apoptosis and Pro-inflammation Associated Alzheimer’s Disease.” J. Med. Chem. 2025 (accepted).
74) Boddu, R. K.; Rani, N.; Schlegel, H. B.;* Nguyen, H. M. * “Why Is Thiol Unexpectedly Less Reactive but More Selective Than Alcohol? Mechanistic Insight into Phenanthroline-Catalyzed Stereoselective O- vs. S-Furanosylations” Org. Biol. Chem. 2025, 23, 328-342.
73) Ghorai, J.; Almounajed, L.; Noori, S.; Nguyen, H. M.* “Cooperative Catalysis in Stereoselective O– and N-Glycosylations with Glycosyl Trichloroacetimidates Mediated by Singly Protonated Phenanthrolinium Salt and Trichloroacetamide.” J. Am. Chem. Soc. 2024, 146, 34413-34426.
72) Trimpin, S.;* Dement, P.; Nguyen, H. M. et al. “New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art.” J. Am. Soc. Mass Spectrom. 2024, 35, 2753−2784.
71) Alom, N. E.; Rani, N.; Schlegel, H. B.;* Nguyen, H. M. * “Highly Stereoselective a-1,2-cis Glycosylated Carboxylic Acids by Phenanthroline Catalysis.” Org. Chem. Front. 2024, 11, 5769-5783.
70) Usman, F.; Gogoi, A. R.; Gutierrez, O.; Nguyen, H. M. “Rhodium-Catalyzed Asymmetric Synthesis of 1,1-Disubstituted Allylic Fluorides” Angew. Chem. Int. Ed. 2023, 62, e202314843.
69) Abdulsalam, H.; Li, J.; Loka, Ravi S.; Sletten, E. T.; Nguyen, H. M. Sulfated Glucosamine-Glucuronic Acid Disaccharide Functionalized Polymers Have a High Affinity for the SARS-CoV-2 Spike Protein.” ACS Med. Chem. Lett. 2023, 14, 1411-1418.
68) Rodrigo, S.; Hazra, A.; Mahajan, J. P.; Nguyen, H. M.; Luo, L. “Overcoming the Potential Window-Limited Functional Group Compatibility by Alternating Current Electrolysis.” J. Am. Chem. Soc. 2023, 145, 21851-21859.
67) Arachchi, M. K.; Schaugaard, R. N.; Schlegel, H. B.; Nguyen, H. M. “Scope and Mechanistic Probe into Asymmetric Synthesis of alpha-Trisubstituted-Alpha-Tertiary Amines via Rhodium Catalysis” J. Am. Chem. Soc. 2023,145, 19642-19654.
66) Wakpal, J.; Pathiranage, P.; Walker, A. Nguyen, H. M. “Rational Design and Expedient Synthesis of Heparan Sulfate Mimetics from Natural Aminoglycosides for Structure and Activity Relationship Studies.” Angew. Chem. Int. Ed. 2023, 62, e202304325
65) Haisha, S.; Nguyen, H. M.; Schlegel, H. S. “Stereoselective Glycosylation Reactions with 2-Deoxyglucose: A Computational Study of Some Catalysts.” Comput. Theor. Chem. 2023, 1224, 114122.
64) Li, J.; Nguyen, H. M. “Phenanthroline Catalysis in Stereoselective 1,2-cis Glycosylations.” Acc. Chem. Res. 2022, 55, 3738-3751.
63) Loka, R. S.; Song, Z.; Sletten, E. T.; Kayla, Y.; Vlodavsky, I.; Zhang, K.; Nguyen, H. M. “Heparan Sulfate Mimicking Glycopolymer Prevents Pancreatic Beta Cell Destruction and Suppresses Inflammatory Cytokine Expression in Islets under the Challenge of Upregulated Heparanase. ” ACS Chemical Biology 2022, 17, 1387-1400.
62) Xu, H.; Schaugaard, R. N.; Li, J.; Schlegel, H. B.; Nguyen, H. M. “Stereoselective 1,2-cis Furanosylations Catalyzed by Phenanthroline.” J. Am. Chem. Soc. 2022, 144, 7441-7456.
61) Schaugaard, R. N.; Nguyen, H. M.; Schlegel, H. B. “Alkyl Radical-Free Cu(I) Photocatalytic Cross-Coupling: A Theoretical Study of Anomerically Specific Photocatalyzed Glycosylation of Pyranosyl Bromide” Inorganic Chemistry 2021, 60, 12801-12812.
60) Luo, L.; Nguyen, H. M. “Alternating current electrolysis for use in organic synthesis.” U.S. Pat. Appl. Publ. 2021, US 20210207274 A1 20210708.
59) Arachchi, M. K.; Nguyen, H. M. “Iridium-Catalyzed Enantioselective Allylic Substitutions of Racemic, Branched Trichloroacetimidates with Heteroatom Nucleophiles: Formation of Allylic C-O, C-N, and C-S Bonds” Advanced Synthesis & Catalysis 2021, 363, 4239-4246.
58) Li, J.; Nguyen, H. M. “A Mechanistic Probe into 1,2-cis Glycoside Formation Catalyzed by Phenanthroline and Further Expansion of Scope” Advanced Synthesis & Catalysis 2021, 363, 4054-4066.
57) Vlodavsky, I.; Barash, U.; Nguyen, H. M.; Yang, S.-M.; Ilan, N. “Biology of the Heparanase-Heparan Sulfate Axis and Its Role in Disease Pathogenesis.” Sem. Thrombosis Hemostasis 2021, 47, 240-253.
56) DeMent, P. M.; Wakpal, J.; Liu, C.; Schaugaard, R. N.; Schlegel, H. B.; Nguyen, H. M. “Phenanthroline-Catalyzed Stereoselective Formation of alpha-1,2-cis-2-Deoxy-2-Fluoro Glycosides” ACS Catalysis. 2021, 11, 2108-2120.
55) Nguyen, H. M.; Zhang, K.; Loka, R. S. “Preparation of heparan sulfate-mimicking glycopolymers as heparanase inhibitors and their use as anti-diabetic compounds.” U.S. Pat. Appl. Publ. 2021, US 20210205350 A1 20210708.
54) Sorlin, A. M.; Fuad, U. O.; English, C. K.; Nguyen, H. M. “Advances in Nucleophilic Allylic Fluorination” ACS Catalysis. 2020, 10, 11980-12010.
53) Zhang, K.; Liu, H.; Song, Z.; Jiang, Y.; Kim , H.; Samavati, L.; Nguyen, H. M.; Yang, Z.-Q. “The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs” iScience 2020, 23, 101503.
52) Rodrigo, S.; Um, C.; Mixdorf, J. C.; Gunasekera, D.; Nguyen, H. M.; Luo, L. “Alternating Current Electrolysis for Organic Electrosynthesis: Trifluoromethylation of (Hetero)arenes” Org. Lett. 2020, 22, 6719-6723.
51) Yu, F.; Dickson, J. L.; Loka, R. S.; Xu, H.; Schaugaard, R. N.; Schlegel, H. B.; Luo, L.; Nguyen, H. M. “Diastereoselective sp3 C–O Bond Formation via Visible Light-Induced, Copper-Catalyzed Cross-Couplings of Glycosyl Bromides with Aliphatic Alcohols” ACS Catalysis. 2020, 10, 5990-6001.
50) Zhu, S.; Li, J.; Loka, R. S.; Song, Z.; Vlodavsky, I.; Zhang, K.; Nguyen, H. M. “Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides” J. Med. Chem. 2020, 63(8), 4227-4255.
49) Zhao, X.; Ranaweera, R.; Mixdorf, J. C.; Nguyen, H. M.; Luo, L. “Lowering interfacial dissolved gas concentration for highly efficient hydrazine oxidation at platinum by fluorosurfactant modulation” ChemElectroChem 2020, 7, 55-58. This paper was featured on the cover picture.
48) Nguyen, H. M.; Loka, R. S.; Sletten, E.; Vlodavsky, I. “Preparation of heparan sulfate-mimicking glycopolymers as heparanase inhibitors and their use as anti-cancer compounds.” PCT Int. Appl. 2020, WO 2020118103 A1 20200611.
47) Zhu, S.; Samala, G.; Sletten, E. T.; Stockdill, J. L.; Nguyen, H. M. “Facile Triflic-Acid-Catalyzed alpha-1,2-cis-Thiol Glycosylations: Scope and Application to the Synthesis of S-Linked Oligosaccharides, Glycolipids, Sublancin Glycopeptide, and Tn/Tf Antigens” Chem. Sci. 2019, 10, 10475-10480. This paper was selected as part of the Chemical Science 2019 HOT Article Collection.
46) Sorlin, A. M.; Mixdorf, J. C.; Rotella, M.; Martin, R.; Gutierrez, O.; Nguyen, H. M. “The Role of Trichloroacetimidate To Enable Iridium-Catalyzed Regio- and Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study” J. Am. Chem. Soc. 2019, 143, 14843-14852.
45) Yu, F.; Li, J.; DeMent, P. M.; Tu, Y-J.; Schlegel, H. B.; Nguyen, H. M. “Phenanthroline-Catalyzed Stereoretentive Glycosylations” Angew. Chem. Int. Ed. 2019, 58, 6957-6961.
44) Sletten, E. R.; Tu, Y-J.; Schlegel, H. B.; Nguyen, H. M. “Are Bronsted Acids the True Promoter of Metal-Triflate-Catalyzed Glycosylations? A Mechanistic Probe into 1,2-cis-Aminoglycoside Formation by Nickel Triflate?” ACS Catalysis. 2019, 9, 2110-2123.
40) Sletten, E. T.; Loka, R. S.; Yu, F.; Nguyen, H. M. “Glycosidase Inhibition by Multivalent Presentation of Heparan Sulfate Saccharides on Bottlebrush Polymers” Biomacromolecules 2017, 18, 3387-3399.
39) Mwenda, E. T.; Nguyen, H. M. “Enantioselective Synthesis of 1,2-Diamines Containing Tertiary and Quaternary Centers through Rhodium-Catalyzed DYKAT of Racemic Allylic Trichloroacetimidates” Org. Lett. 2017, 19, 4814-4817
38) Loka, R. S.; Yu, F.; Sletten, E. T.; Nguyen, H. M. “Design, Synthesis, and Evaluation of Heparan Sulfate Mimicking Glycopolymers for Inhibiting Heparanase Activity” Chem. Commun. 2017, 53, 9163-9166.
37) Sletten, E. T.; Loka, R. S; Fairweather, A. E. R; Nguyen, H. M. “Nickel-Catalyzed Stereoselective Formation of 1,2-cis-2-Aminoglycosides” in Selective Glycosylations: Synthetic Methods and Catalysts”, Edited By Clay S. Bennett, Wiley-VCH, 2017, pp. 173-207.
(36) Silverman, R. B.; Mukherjee, M.; Nguyen, H. M. “2-Imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase and their preparation.” PCT Int. Appl. 2016, WO 2016007966 A2 20160114
35) Sletten, E. T; Ramadugu, S. K.; Nguyen, H. M. “Utilization of Bench-Stable and Readily Available Nickel (II) Triflate for Access to 1,2-Cis-2-Aminoglycosides.”Carbohydrate Research 2016, 435, 195-207.
34) Park, N. H.; Sletten, E. T.; McKay, M. J.; Nguyen, H. M. “Palladium- and Nickel-Catalyzed Stereoselective Synthesis of Glycosyl Trichloroacetamides and Their Conversion to Alpha- and Beta-Urea Glycosides.” in Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience, Edited By Zbigniew J. Witczack and Roman Bielski, Wiley & Sons, 2016, pp. 297-324.
33) Loka, R. S.; McConnell, M. S.; Nguyen, H. M. “Studies of Highly-Ordered Heterodiantennary Mannose/Glucose-Functionalized Polymers and Concanavalin A Protein Interactions Using Isothermal Titration Calorimetry.”Biomacromolecules 2015, 16, 4013-4021.
32) Zhang, Q.; Stockdale, D. P.; Mixdorf, J. C.; Topczewski, J. J.; Nguyen, H. M. “Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates.” J. Am. Chem. Soc. 2015, 137, 11912-11915.
31) Zhang, Q.; Mixdorf, J. C.; Reynders III, G. J.; Nguyen, H. M. “Rhodium-Catalyzed Benzylic Fluorination of Trichloroacetimidates with Triethylamine Trihydrofluoride.”Tetrahedron. 2015, 71, 5932-5938 (Special Issue for Professor Trost’s 2014 Tetrahedron Award).
30 Yu, F.; McConnell, M. S.; Nguyen, H. M. “Scalable Synthesis of Fmoc-Protected GalNAc-Threonine Amino Acid and TN Antigen via Nickel Catalysis.” Org. Lett. 2015, 17, 2018-2021.
29) Sletten, E. T.; Svec, R. L.; Nguyen, H. M. “Synthesis of a polymerizable, bivalent glycan mimetic of the HIV envelope spike gp120.”Tetrahedron Lett. 2015, 56, 3473-3476 (Memorial Issue for Professor Harry Wasserman)
28 Arnold, J. S; Zhang, Q.; Nguyen, H. M. “Transition-Metal-Catalyzed Allylic Substitutions of Trichloroacetimidates.”Eur. J. Org. Chem. 2014, 4925-4948.
27) McKay, M. J.; Park, N. H.; Nguyen, H. M. “Investigations of Scope and Mechanism of Nickel-Catalyzed Transformations of Glycosyl Trichloroacetimidates to Glycosyl Trichloroacetamides and Subsequent, Atom-Economical, One-Step Conversion to alpha-Urea-Glycosides.” Chem. Eur. J. 2014, 20, 8691-8701.
26) Arnold, J. S.; Mwenda, E. T.; Nguyen, H. M. “Rhodium-Catalyzed Sequential Allylic Amination and Olefin Hydroacylation Reactions: Enantioselective Synthesis of Seven-Membered Nitrogen Heterocycles.” Angew. Chem. Int. Ed. 2014, 53, 3688-3692. This article was selected as a “HOT PAPER.”
25) Zhang, Q.; Nguyen, H. M. “Rhodium-Catalyzed Regioselective Ring Opening of Vinyl Epoxides with Triethylamine Trihydrofluoride -Formation of Allylic Fluorohydrins.” Chem. Sci.2014, 5, 291-296.
24) McKay, M. J.; Nguyen, H. M. “Recent Development in the Synthesis of Glycosyl Ureas.” Carbohydrate Research, 2014, 385, 18-44
23) McConnell, M. S.; Mensah, E. A.; Nguyen, H. M. “Nickel-Catalyzed Stereoselective alpha-Glycosylation of Inositols – Application to the Synthesis of GPI Anchor Pseudo-Oligosaccharides.” Carbohydrate Research, 2013, 381, 146-152.
22) Arnold, J. S.; Nguyen, H. M. “Rhodium-Catalyzed Asymmetric Amination of Allylic Trichloroacetimidates.” Synthesis, 2013, 45, 2101-2108.
21) McConnell, M.S.; Yu, F.; Nguyen, H. M. “Nickel-Catalyzed alpha-Glycosylation of C(1)-Hydroxyl Group of Inositol Acceptors: A Formal Synthesis of Mycothiol.” Chem. Commun. 2013, 49, 4313-4315.
20) Arnold, J. S.; Cizio, G.; Nguyen, H. M. “Rhodium-Catalyzed Regio- and Enantioselective Amination of Racemic Secondary Allylic Trichloroacetimidates with Acyclic N- Methyl Anilines.” Chem. Commun.2012, 48, 11531-11533.
19) Yu, F.; Nguyen, H. M. “Studies on the Selectivity Between Nickel-Catalyzed 1,2-Cis-2-Amino Glycosylation of Hydroxyl Groups of Thioglycosides with C(2)-Substituted Benzylidene N-Phenyl Trifluoroacetimidates and Intermolecular Aglycon Transfer of the Sulfide Group. ” J. Org. Chem. 2012, 77, 7730-7343.
18) McKay, M. J.; Nguyen, H. M. “Recent Advances in Transition Metal-Catalyzed Glycosylation.” ACS Catalysis 2012,2, 1563-1595.
17) Arnold, J. S.; Nguyen, H. M. “Rhodium-Catalyzed Dynamic Kinetic Assymetric Transformations of Racemic Tertiary Allylic Trichloroacetimidates with Anilines. ” J. Am. Chem. Soc. 2012, 134, 8380-8383.
16) Topczewski, J. J.; Tewson, T. J.; Nguyen, H. M. “Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates.” J. Am. Chem. Soc. 2011, 133, 19318-19321.
15) Arnold, J. A.; Cizio, G.T.; Nguyen, H. M. “Synthesis of a,a-Disubstituted Allylic Aryl Amines by Rhodium-Catalyzed Amination of Tertiary Allyic Trichloroacetimidates.”Org. Lett. 2011, 13, 5576-5578.
14) Mensah, E. A.; Yu, F.; Nguyen, H. M. “Nickel-Catalyzed Stereoselective Glycosylation with C(2)-N-Substituted Benzylidene D-Glucosamine and Galactosamine Trichloroacetimidates for the Formation of 1,2-cis-2-Amino Glycosides. Applications to the Synthesis of Heparin Disaccharides, GPI Anchor Psuedodisaccharides, and alpha-GalNAc.” J. Am. Chem. Soc.2010, 132, 14288-14302.
13) Arnold, J. S.; Stone, R. F.; Nguyen, H. M. “Rhodium-Catalyzed Regioselective Amination of Secondary Allylic Trichloroacetimidates with Unactivated Aromatic Amines.” Org. Lett.2010, 12, 4580-4583.
12) Mensah, E. A.; Nguyen, H. M. “Nickel-Catalyzed Stereoselective Formatin of alpha-2-Deoxy-2-Amino-Glycosides.” J. Am. Chem. Soc.2009, 131, 8778-8780.
11) McKay, M. J.; Naab, B. D; Mercer, G. J.; Nguyen, H. M. “Selective Formation of beta-O-Aryl Glycosides in the Absence of the C(2)-Ester Neighboring Group.” J. Org. Chem.2009, 74, 4705-4711.
10) Park, N. H.; Nguyen, H. M. “Stereoselective Rearrangement of Trichloroacetimidates: Application to the Stereoselective Synthesis of Glycosyl Ureas.” Org Letters.2009, 11, 2433-2436.
9) Mensah, E. A.; Azzarelli, J. A.; Nguyen, H. M. “Palladium-Controlled beta-Selective Glycosylation in the Absence of the C(2)-Ester Participatory Group.” J. Org. Chem., 2009, 74, 1650-1657.
8) Mercer, G. J.; Yang, J.; McKay, M. J.; Nguyen, H. M. “Palladium(II)-Catalyzed Rearrangement of Glycal Trichloroacetimidates: Application to the Stereoselective Synthesis of Glycosyl Ureas.” J. Am. Chem. Soc., 2008, 130, 11210-11218.
7) Yang, J.; Cooper-Vanosdell, C.; Mensah, E. A.; Nguyen, H. M. “Cationic Palladium(II)-Catalyzed Stereoselective Glycosylation with alpha-Glycosyl Trichloroacetimidates.”J. Org. Chem., Featured Article, 2008, 73, 794-800
6) Yang, J.; Mercer, G, J.; Nguyen, H. M. “Palladium-Catalyzed Glycal Imidate Rearrangement: Stereoselective Formation of alpha- and beta-Glycosyl Trichloroacetamides.”Org. Lett. 2007, 9, 4231-4234.
5) Schuff, B. P, Mercer, G. J, Nguyen, H. M. “Palladium-Catalyzed Stereoselective Synthesis of a-O-Glycosides.”Org. Lett.2007, 9, 3173-3176.
4) Trost, B. M.; Nguyen, H. M.; Koradin, C. “Synthesis of a Tricyclic Core of Rameswaralide.” Invited a Special Issue in Honor of Professor Harry Wasserman, Tetrahedron. Lett. 2011, 52, 2033 – 2036.
3) Nguyen, H. M.; Chen, Y.; Duron, S. G.; Gin, D. Y. “Sulfide-Mediated Dehydrative Glycosylation.” J. Am. Chem. Soc. 2001, 123, 8766 – 8772.
2) Nguyen, H. M.; Poole, J. L.; Gin, D. Y. “Chemoselective Iterative Dehydrative Glycosylation.” Angew. Chem. Int. Ed. 2001, 40, 414 – 417.
1) Rajopadhye, M.; Harris, A. R.; Nguyen, H. M.; Overoye, K. L.; Bartis, J.; Edwards, D. S.; Liu, S.; Onthank, D.; Barrett, J. A. “The Synthesis and Evaluation of the Tc-99m and In-111 Complexes of Cyclic RGD-Peptide Antagonists for the Integrin avb3.” J. Nucl. Med. 2000, 41, 259P.