PUBLICATIONS

48) Sorlin, A. M.; Fuad, U. O.; English, C. K.; Nguyen, H. M. “Advances in Nucleophilic Allylic Fluorination” ACS Catal. 2020, 10, 11980-12010.

47) Zhang, K.; Liu, H.; Song, Z.; Jiang, Y.; Kim , H.; Samavati, L.; Nguyen, H. M.; Yang, Z.-Q. “The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs” iScience 2020, 23, 101503.

46) Rodrigo, S.; Um, C.; Mixdorf, J. C.; Gunasekera, D.; Nguyen, H. M.; Luo, L. “Alternating Current Electrolysis for Organic Electrosynthesis: Trifluoromethylation of (Hetero)arenes” Org. Lett. 2020, 22, 6719-6723.

45) Yu, F.; Dickson, J. L.; Loka, R. S.; Xu, H.; Schaugaard, R. N.; Schlegel, H. B.; Luo, L.; Nguyen, H. M. “Diastereoselective sp3 C–O Bond Formation via Visible Light-Induced, Copper-Catalyzed Cross-Couplings of Glycosyl Bromides with Aliphatic Alcohols” ACS Catal. 2020, 10, 5990-6001.

44) Zhu, S.; Li, J.; Loka, R. S.; Song, Z.; Vlodavsky, I.; Zhang, K.; Nguyen, H. M. “Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides” J. Med. Chem. 2020, 63(8), 4227-4255.

43) Zhao, X.; Ranaweera, R.; Mixdorf, J. C.; Nguyen, H. M.; Luo, L. “Lowering interfacial dissolved gas concentration for highly efficient hydrazine oxidation at platinum by fluorosurfactant modulation” ChemElectroChem 2020, 7, 55-58. This paper was featured on the cover picture.

42) Zhu, S.; Samala, G.; Sletten, E. T.; Stockdill, J. L.; Nguyen, H. M. “Facile Triflic-Acid-Catalyzed alpha-1,2-cis-Thiol Glycosylations: Scope and Application to the Synthesis of S-Linked Oligosaccharides, Glycolipids, Sublancin Glycopeptide, and Tn/Tf Antigens” Chem. Sci. 2019, 10, 10475-10480.  This paper was selected as part of the Chemical Science 2019 HOT Article Collection.

41) Sorlin, A. M.; Mixdorf, J. C.; Rotella, M.; Martin, R.; Gutierrez, O.; Nguyen, H. M. “The Role of Trichloroacetimidate To Enable Iridium-Catalyzed Regio- and Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study” J. Am. Chem. Soc. 2019, 143, 14843-14852.

40) Yu, F.; Li, J.; DeMent, P. M.; Tu, Y-J.; Schlegel, H. B.; Nguyen, H. M. “Phenanthroline-Catalyzed Stereoretentive Glycosylations” Angew. Chem. Int. Ed. 2019, 58, 6957-6961.

39) Sletten, E. R.; Tu, Y-J.; Schlegel, H. B.; Nguyen, H. M. “Are Bronsted Acids the True Promoter of Metal-Triflate-Catalyzed Glycosylations? A Mechanistic Probe into 1,2-cis-Aminoglycoside Formation by Nickel Triflate?” ACS Catal. 2019, 9, 2110-2123.

38) Loka, R. S..; Sletten, E. T.; Barash, U.; Vlodavsky, I.; Nguyen, H. M.  “Specific Inhibition of Heparanase by a Gylcopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice” ACS Appl. Mater. Interfaces 2019, 11, 244-254.
37) Mixdorf, J. M.; Sorlin, A. M.; Dick, D. W.; Nguyen, H. M. “Iridium-Catalyzed Radiosynthesis of Branched Allylic [18F]Fluorides”  Org. Lett. 2019, 21 (1), 60-64.
36) Mixdorf, J. M.; Sorlin, A. M.; Zhang, Q.; Nguyen, H. M. “Asymmetric Synthesis of Allylic Fluorides via Fluorination of Racemic Allylic Trichloroacetimidates Catalyzed by a Chiral-Iridium Complex”  ACS Catal. 2018, 8 (2), 790-801.

35) Sletten, E. T.; Loka, R. S.; Yu, F.; Nguyen, H. M. “Glycosidase Inhibition by Multivalent Presentation of Heparan Sulfate Saccharides on Bottlebrush Polymers”  Biomacromolecules 2017, 18, 3387-3399.

34) Mwenda, E. T.; Nguyen, H. M. “Enantioselective Synthesis of 1,2-Diamines Containing Tertiary and Quaternary Centers through Rhodium-Catalyzed DYKAT of Racemic Allylic Trichloroacetimidates”  Org. Lett. 2017, 19, 4814-4817

33) Loka, R. S.; Yu, F.; Sletten, E. T.; Nguyen, H. M. “Design, Synthesis, and Evaluation of Heparan Sulfate Mimicking Glycopolymers for Inhibiting Heparanase Activity”  Chem. Commun. 2017, 53, 9163-9166.

 

32) Sletten, E. T.; Loka, R. S; Fairweather, A. E. R; Nguyen, H. M.* “Nickel-Catalyzed Stereoselective Formation of 1,2-cis-2-Aminoglycosides” in Selective Glycosylations: Synthetic Methods and Catalysts”, Edited By Clay S. Bennett, Wiley-VCH, 2017, pp. 173-207.

31) Sletten, E. T; Ramadugu, S. K.; Nguyen, H. M. “Utilization of Bench-Stable and Readily Available Nickel (II) Triflate for Access to 1,2-Cis-2-Aminoglycosides.” Carbohydrate Research 2016, 435, 195-207. 

30) Park, N. H.; Sletten, E. T.; McKay, M. J.; Nguyen, H. M. “Palladium- and Nickel-Catalyzed Stereoselective Synthesis of Glycosyl Trichloroacetamides and Their Conversion to Alpha- and Beta-Urea Glycosides.” in Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience, Edited By Zbigniew J. Witczack and Roman Bielski, Wiley & Sons, 2016, pp. 297-324.

29) Loka, R. S.; McConnell, M. S.; Nguyen, H. M. “Studies of Highly-Ordered Heterodiantennary Mannose/Glucose-Functionalized Polymers and Concanavalin A Protein Interactions Using Isothermal Titration Calorimetry.” Biomacromolecules 2015, 16, 4013-4021.

28) Zhang, Q.; Stockdale, D. P.; Mixdorf, J. C.; Topczewski, J. J.; Nguyen, H. M. “Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates.” J. Am. Chem. Soc. 2015, 137, 11912-11915.

27) Zhang, Q.; Mixdorf, J. C.; Reynders III, G. J.; Nguyen, H. M. “Rhodium-Catalyzed Benzylic Fluorination of Trichloroacetimidates with Triethylamine Trihydrofluoride.” Tetrahedron2015, 71, 5932-5938 (Special Issue for Professor Trost’s 2014 Tetrahedron Award).

26) Yu, F.; McConnell, M. S.; Nguyen, H. M. “Scalable Synthesis of Fmoc-Protected GalNAc-Threonine Amino Acid and TN Antigen via Nickel Catalysis.” Org. Lett. 2015, 17, 2018-2021.

25) Sletten, E. T.; Svec, R. L.; Nguyen, H. M. “Synthesis of a polymerizable, bivalent glycan mimetic of the HIV envelope spike gp120.” Tetrahedron Lett. 2015, 56, 3473-3476 (Memorial Issue for Professor Harry Wasserman)

24) Arnold, J. S; Zhang, Q.; Nguyen, H. M. “Transition-Metal-Catalyzed Allylic Substitutions of Trichloroacetimidates.” Eur. J. Org. Chem. 20144925-4948.

23) McKay, M. J.; Park, N. H.; Nguyen, H. M. “Investigations of Scope and Mechanism of Nickel-Catalyzed Transformations of Glycosyl Trichloroacetimidates to Glycosyl Trichloroacetamides and Subsequent, Atom-Economical, One-Step Conversion to alpha-Urea-Glycosides.” Chem. Eur. J. 2014, 20, 8691-8701 .

22) Arnold, J. S.; Mwenda, E. T.; Nguyen, H. M. “Rhodium-Catalyzed Sequential Allylic Amination and Olefin Hydroacylation Reactions: Enantioselective Synthesis of Seven-Membered Nitrogen Heterocycles.” Angew. Chem. Int. Ed.2014, 53, 3688-3692.  This article was selected as a “HOT PAPER.”

21) Zhang, Q.; Nguyen, H. M. “Rhodium-Catalyzed Regioselective Ring Opening of Vinyl Epoxides with Triethylamine Trihydrofluoride -Formation of Allylic Fluorohydrins.” Chem. Sci. 2014, 5, 291-296.

20) McKay, M. J.; Nguyen, H. M. “Recent Development in the Synthesis of Glycosyl Ureas.” Carbohydrate Research2014, 385, 18-44

19) McConnell, M. S.; Mensah, E. A.; Nguyen, H. M. “Nickel-Catalyzed Stereoselective alpha-Glycosylation of Inositols – Application to the Synthesis of GPI Anchor Pseudo-Oligosaccharides.” Carbohydrate Research2013, 381, 146-152.

18) Arnold, J. S.; Nguyen, H. M. “Rhodium-Catalyzed Asymmetric Amination of Allylic Trichloroacetimidates.” Synthesis2013, 45, 2101-2108.

17) McConnell, M.S.; Yu, F.; Nguyen, H. M. “Nickel-Catalyzed alpha-Glycosylation of C(1)-Hydroxyl Group of Inositol Acceptors: A Formal Synthesis of Mycothiol.” Chem. Commun. 2013, 49, 4313-4315.

16) Arnold, J. S.; Cizio, G.; Nguyen, H. M. “Rhodium-Catalyzed Regio- and Enantioselective Amination of Racemic Secondary Allylic Trichloroacetimidates with Acyclic N- Methyl Anilines.” Chem. Commun. 2012 , 48, 11531-11533.

15) Yu, F.; Nguyen, H. M. “Studies on the Selectivity Between Nickel-Catalyzed 1,2-Cis-2-Amino Glycosylation of Hydroxyl Groups of Thioglycosides with C(2)-Substituted Benzylidene N-Phenyl Trifluoroacetimidates and Intermolecular Aglycon Transfer of the Sulfide Group. ” J. Org. Chem. 2012 , 77, 7730-7343.

14) McKay, M. J.; Nguyen, H. M. “Recent Advances in Transition Metal-Catalyzed Glycosylation. ” ACS Catalysis 2012,2, 1563-1595.

13) Arnold, J. S.; Nguyen, H. M. “Rhodium-Catalyzed Dynamic Kinetic Assymetric Transformations of Racemic Tertiary Allylic Trichloroacetimidates with Anilines. ” J. Am. Chem. Soc. 2012, 134, 8380-8383.

12) Topczewski, J. J.; Tewson, T. J.; Nguyen, H. M. “Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates.” J. Am. Chem. Soc. 2011, 133, 19318-19321.

11) Arnold, J. A.; Cizio, G.T.; Nguyen, H. M. “Synthesis of a,a-Disubstituted Allylic Aryl Amines by Rhodium-Catalyzed Amination of Tertiary Allyic Trichloroacetimidates.” Org. Lett. 2011, 13, 5576-5578.

10) Mensah, E. A.; Yu, F.; Nguyen, H. M. “Nickel-Catalyzed Stereoselective Glycosylation with C(2)-N-Substituted Benzylidene D-Glucosamine and Galactosamine Trichloroacetimidates for the Formation of 1,2-cis-2-Amino Glycosides. Applications to the Synthesis of Heparin Disaccharides, GPI Anchor Psuedodisaccharides, and alpha-GalNAc.” J. Am. Chem. Soc. 2010, 132, 14288-14302.

9) Arnold, J. S.; Stone, R. F.; Nguyen, H. M. “Rhodium-Catalyzed Regioselective Amination of Secondary Allylic Trichloroacetimidates with Unactivated Aromatic Amines.” Org. Lett. 2010, 12, 4580-4583.

8) Mensah, E. A.; Nguyen, H. M. “Nickel-Catalyzed Stereoselective Formatin of alpha-2-Deoxy-2-Amino-Glycosides.” J. Am. Chem. Soc. 2009, 131, 8778-8780.

7) McKay, M. J.; Naab, B. D; Mercer, G. J.; Nguyen, H. M. “Selective Formation of beta-O-Aryl Glycosides in the Absence of the C(2)-Ester Neighboring Group.” J. Org. Chem. 2009, 74, 4705-4711.

6) Park, N. H.; Nguyen, H. M. “Stereoselective Rearrangement of Trichloroacetimidates: Application to the Stereoselective Synthesis of Glycosyl Ureas.” Org Letters.2009, 11, 2433-2436.

5) Mensah, E. A.; Azzarelli, J. A.; Nguyen, H. M. “Palladium-Controlled beta-Selective Glycosylation in the Absence of the C(2)-Ester Participatory Group.” J. Org. Chem.2009, 74, 1650-1657.

4) Mercer, G. J.; Yang, J.; McKay, M. J.; Nguyen, H. M. “Palladium(II)-Catalyzed Rearrangement of Glycal Trichloroacetimidates: Application to the Stereoselective Synthesis of Glycosyl Ureas.” J. Am. Chem. Soc. 2008, 130, 11210-11218.

3) Yang, J.; Cooper-Vanosdell, C.; Mensah, E. A.; Nguyen, H. M. “Cationic Palladium(II)-Catalyzed Stereoselective Glycosylation with alpha-Glycosyl Trichloroacetimidates.” J. Org. Chem., Featured Article2008, 73, 794-800

2) Yang, J.; Mercer, G, J.; Nguyen, H. M. “Palladium-Catalyzed Glycal Imidate Rearrangement: Stereoselective Formation of alpha- and beta-Glycosyl Trichloroacetamides.” Org. Lett. 2007, 9, 4231-4234.

1) Schuff, B. P, Mercer, G. J, Nguyen, H. M.  “Palladium-Catalyzed Stereoselective Synthesis of a-O-Glycosides.” Org. Lett. 2007, 9, 3173-3176.