Publications – Sadagurski Lab

Contents

2024

Rutkoski R., Debarba LK., Stilgenbauer L., Rosenthal T., *Sadagurski M., and *Nagorny P. Selective (a)-L-Rhamnosylation and neuroprotective activity exploration of cardiotonic steroids. ACS Medicinal Chemistry Letters. Accepted, Jan 2024 http://Selective(α)‑L‑RhamnosylationandNeuroprotectiveActivityExplorationofCardiotonicSteroids

2023

Debarba LK., Jayarathne HSM, Stilgenbauer L., Terra dos Santos ALR, Koshko L., Scofield S., Sullivan R., Mandal A., Klueh U., Sadagurski M. Microglial NF-κB signaling deficiency protects against metabolic disruptions caused by volatile organic compound via modulating the hypothalamic transcriptome. https://www.biorxiv.org/content/10.1101/2023.11.08.566279v1

J. Ding, Y. Song, C. Liu, M Sadagurski. Editorial: Environmental toxicity in reproduction. Frontiers in Physiology, Sec. Developmental Physiology, Dec 2023

K Zhang, C Liu, M Sadagurski, Q Sun. Editorial: Environmental stressors and metabolic disease. Frontiers in Endocrinology, 2023

Kesserwan S., Sadagurski M., Mao L., Klueh U. Mast Cell Deficiency in Mice Alleviates Insulin Phenolic Preservative-induced Inflammation. Biomedicines (ISSN 2227-9059). Accepted, August 2023

Stilgenbauer L., de Lima L.B.M, Debarba L.K, Khan M., Koshko L., Kopchick J.J., Bartke A., Schneider A., Sadagurski M. Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in aged mice in a sex-specific manner. GeroScience

Koshko L., Scofield S., Debarba L., Stilgenbauer L., Sacla M., Fakhoury P., Jayarathne H., Perez-Mojica E, Griggs E., Lempradl A., Sadagurski M. Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life. Chemosphere, In Press

Adelabu I., Chowdhury R.H., Nantogma S., ,Oladun C., Ahmed F., Stilgenbauer L., Sadagurski M
Theis T., Goodson B., Chekmenev E.Y. Efficient SABRE-SHEATH Hyperpolarization of Potent Branched chain-amino-acid Metabolic Probe [1-13C]ketoisocaproate. Metabolites, Accepted.

Jayarathne H., Liu W., Sadagurski M. Repurposing Canagliflozin to target brain aging. Aging 2023.

2022

Mitkin N.A., Pavshintсev V.V., Sukhanova I.A., Doronin I.I., Babkin G.A., Sadagurski M., Malyshev A.V. The novel peptide CHM-273S has therapeutic potential for metabolic disorders: Evidence from in vitro studies and high-sucrose diet and high-fat diet rodent models. Pharmaceutics, Accepted, 2022.

Ding J., Maxwell A., Adzibolosu N., Hu A., Debarba L., Koshko L., Ramadoss J., Nguyen A., Richards D., Liao A., Sadagurski M., Mor G. Intrinsic Sexual Dimorphism in the Placenta Determines the Differential Response to Benzene Exposure. iScience, Accepted, 2023

Snyder JM., Galecki A., Kumar S., Sadagurski M., Casey K., Harrison D., Jayarathne H., Miller RA., Rosenthal, Strong R., Ladiges WC. Canagliflozin Retards Age-Related Lesions in Heart, Kidney, Liver, and Adrenal Gland in Genetically Heterogenous Male Mice. GeroScience, 2022.

Koshko L., Scofield S., Mor G., Sadagurski M. Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming. Frontiers in Endocrinology 2022.

Jayarathne H., Debarba LK., Jaboro J., Miller RA, Sadagurski M. Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice. Aging Cell 2022. BioRxiv

2021

Debarba LK., Jayarathne H., Miller RA, Garratt M, Sadagurski M. 17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy. J Gerontol A Biol Sci Med Sci. July 2021.

Lima J., Debarba L.K., Rupp A.C., Qi N., Ubah C., Khan M., Ayyar I., Didyuk O., Sandoval D.A., Sadagurski M. ARC^GHR Neurons Regulate Muscle Glucose Uptake. Cells 2021, 10(5), 1093; https://doi.org/10.3390/cells10051093.

Lima J., Ubah C., Debarba L.K., Ayyar I., Didyuk O., Sadagurski M. Hypothalamic GHR—SIRT1 Axis in Fasting. Cells 2021, 10(4), 891; https://doi.org/10.3390/cells10040891

^#Koshko L., ^#Debarba L.K., Sacla M., Lima J., Didyuk O., Fakhoury P., Sadagurski M. Metabolic Reprogramming by In Utero Maternal Benzene Exposure. Toxicological Sciences. Jan 2021. In Press.

2020

Richard A. Miller, David E. Harrison, David B. Allison, Molly A. Bogue, Lucas K. Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej T. Galecki, W. Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin Javors, Warren Ladiges, Francesca Macchiarini, James F. Nelson, Peter C. Reifsnyder, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Daniel L. Smith, Jr., Jessica M. Snyder, David B. Lombard, and Randy Strong. Canagliflozin extends lifespan in genetically heterogeneous male but not female mice. JCI Insight. In Press

Lima J., Debarba L., Sadagurski M. Meeting abstracts from the 2020 International Meeting on GH/IGF: actions in the shadow of COVID19. Novel roles for hypothalamic growth hormone (GH) axis in metabolic regulation. Pituitary volume 23, pages 2–35(2020)

Lima J., Debarba L.K., Khan M., Ubah C., Didyuk O., Ayyar I., Koch M., Sadagurski M. GHR-expressing neurons in the hypothalamic arcuate nucleus regulate glucose metabolism and energy homeostasis. BioRxiv, Submitted. 2020

Debarba LK., Mulka, A., Lima, J.B.M., Awada, AA., Didyuk, O., Fakhoury, P., Koshko, L., Zhang, K., Klueh, U., Sadagurski, M. Acarbose protects from central and peripheral metabolic imbalance induced by benzene exposure. Brain Behavior and Immunity. Accepted, May 2020

Sutton A , Gonzalez I , Sadagurski M, Rajala M, Lu C, Allison MB, Adams JM, Myers MG, White MF, OlsonDP. Paraventricular hypothalamic IRS4 neuronal activity is required for normal energy balance. Scientific Reports. 2020 March

2019

Sadagurski M*, Debarba L^#, Werneck-de-Castro J. P., Awada A.A.^#, Baker T., Bernal-Mizrachi E. Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to diet rich in high fat and branched chain amino acids. Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E526-E534.

2017

Cady G, Sadagurski M. Targeting neuroinflammation – a potential for anti-aging interventions. Aging 2017, 9, 1951-1952.

Cady G, Landeryou T, Kopchick JJ, List EO, Berryman DE, Elias C, Myers MG, Miller RA, Sadagurski M. Growth hormone receptor (GHR) in nutrient-sensing neurons regulates hepatic glucose production. Molecular Metabolism 2017. Mar 16;6(5):393-405.

Sadagurski M*, Cady G, Miller RA . Anti-Aging Drugs Reduce Hypothalamic Inflammation in a Sex-Specific Manner. Aging Cell 2017 Aug 16(4)

Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF. Tricyclic compounds that increase IRS2 in human Islets and promote beta-cell growth and function in mice. J Clin Invest. Insight. 2016 Mar 17

Sadagurski M*, Landeryou T, Cady G, Kopchick JJ, List EO, Berryman DE, Bartke A, and Miller RA. Growth Hormone Modulates Hypothalamic Inflammation in Long-Lived Pituitary Dwarf Mice. Aging Cell 2015 Aug 12

Sadagurski M*, Landeryou T, Cady G, Bartke A, Bernal-Mizrachi E and Miller RA. Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter (CL) mice. Physiological Reports 2015 Apr 3(4)

Tallaksen-Greene S, Sadagurski M, Zeng L, Mauch R, Perkins M, Miller RA, Paulson H, and Albin R. Differential Effects of Delayed Aging on Phenotype and Striatal Pathology in a Murine Model of Huntington Disease. J Neuroscience. 2014 Nov 19;34(47)

Sadagurski M*, Landeryou T, Blandino-Rosano M, Cady G, Elghazi L, Meister D, See L, Bartke A, Bernal-Mizrachi E and Miller RA. Long-lived crowded litter (CL) mice exhibit lasting effects on insulin sensitivity and energy homeostasis. Am J Physiol Endocrinol Metab. 2014 Apr 15.

Sadagurski M, Dong X, Myers MG and White MF. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Molecular Metabolism. 2013 Oct 23;3(1):55-63.

Sadagurski M and White MF. Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am. 2013 Mar;42(1): 127-148.

Sadagurski M, Leshan RL, Patterson C, Rozzo A, Dong X, Skorupski J, Depinho R Myers MG, and White MF. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metabolism. 2012 May 2;15 (5):703-712.

Sadagurski M, Cheng Z, Rozzo A, Palazzolo I, Dong X, Krainc D and White MF. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest. 2011 Oct 3;121(10):4070-81.

Sadagurski M, Norquay L, Farhang-Fallah J, Copps K, and White MF. Human IL6 enhances leptin action in mice. Diabetologia. 2010 Mar;53(3):525-35.

Carew RM, Sadagurski M, Goldschmeding R, Martin F, White MF and Brazil DP. (2010) Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β. BMC Developmental Biology 2010, 10:73.

Sadagurski M, Nofech-Mozes S, Spravchikov N, Weingarten G, Teruachi Y, White MF, Kadowaki T and Wertheimer E. Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. J Cell Physiol. 2007 Nov;213(2):519-27.

Sadagurski M, Yakar S, Weingarten G, Holzenberger M, Rhodes CJ, Breitkreutz D, LeRoith D and Wertheimer E. IGF-1 receptor signaling regulates skin development and inhibits skin keratinocytes differentiation. Mol Cell Biol. 2006 Apr;26(7):2675-87.

Sadagurski M, Weingarten G, Rhodes CJ, White MF and Wertheimer E. Insulin receptor substrate 2 (IRS-2) plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem. 2005 Apr 15; 280(15):14536-44.