Genetic, Molecular, and Cellular Biology Laboratory
11/23/2023: Publication alert – our research article entitled “Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome” is published in Nature Metabolism!
11/23/2023: Publication alert – our research article entitled “Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome” is published in Nature Metabolism!
This highly collaborative, cross-disciplinary study provides an exciting new framework for understanding the potential cause of Barth syndrome! This research, which utilized genetic, biophysical, lipidomic, and computational approaches, as well as a wide array of Barth syndrome research models, addresses a gap in our understanding of Barth syndrome by identifying peroxidase complex formation as a primary, direct consequence of impaired cardiolipin remodeling.
