1/26/2024: Publication alert – our latest research article entitled “Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1)” has been accepted for publication in The Journal of Biological Chemistry!

March 4, 2024March 4, 2024 gv2028

This research, carried out primarily by Dr. Zhuqing Liang, utilized genetic and biochemical approaches to elucidate one of the mechanisms underlying decreased pyruvate dehydrogenase (PDH) activity in Tafazzin-deficient models of Barth syndrome (BTHS). This mechanism could help explain how cardiolipin deficiency leads to metabolic dysregulation in BTHS.

View article here: https://doi.org/10.1016/j.jbc.2024.105697

Written by gv2028

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