Chisom Onu and Abu Ramim have been awarded ATTRACT funding from the CBI program. The goal of ATTRACT funding is to: 1) Provide PhD students an opportunity to gain new knowledge and develop new skills/expertise in chemical biology.2) Encourage PhD Read More …
5/24/2024: Greenberg lab members Ramim, Vikalp, and Tyler receive Barth Syndrome Foundation travel awards to attend The 2024 Barth Syndrome Foundation Biennial Scientific, Medical and Family Conference!
Ramim, Vikalp, and Tyler will travel to Bonita Springs, Florida, USA to present their research at the The 2024 Barth Syndrome Foundation Biennial International Scientific, Medical and Family conference. “Join the Barth Syndrome Foundation (BSF) for our long-awaited event, bringing Read More …
5/15/2024: Publication alert – our latest primary research article entitled “Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells” has been accepted for publication in Scientific Reports!
Dr. Zhuqing Liang publishes yet another article detailing the complex interplay between cardiolipin and pyruvate dehydrogenase! This research details a new mechanism whereby cardiolipin-deficiency leads to decreased pyruvate dehydrogenase activity through the genetic regulation of pyruvate dehydrogenase kinase 4. View Read More …
5/1/2024: Dr. Zhuqing Liang and PhD candidate Chisom Onu both gave 15 minutes talks at the 11th annual Lipids@Wayne symposium!
Dr. Zhuqing Liang gave a 15 minute presentation entitled “Dual mechanisms contributing to pyruvate dehydrogenase activity deficiency in a Barth syndrome cell model”. Dr. Liang’s presentation centered around describing two mechanisms by which cardiolipin-deficiency alters the activity of pyruvate dehydrogenase. Read More …
5/1/2024: Four Greenberg lab members present posters at the 11th annual Lipids@Wayne Symposium!
More about Lipids@Wayne and the 11th annual symposium can be found here: Lipids@Wayne website Tyler Ralph-Epps took first place in the poster presentation competition. Tyler’s poster centers around one potential hypothesis as to why acyl-carnitine concentrations are increased in CL-deficient Read More …
3/19/2024: Publication alert – our latest review article entitled “Insights into the roles of inositol hexakisphosphate kinase 1 (IP6K1) in mammalian cellular processes” has been accepted for publication in The Journal of Biological Chemistry!
This review article, written by PhD student Mohamed Chakkour, has been published in The Journal of Biological Chemistry! In this article, Mohamed details the intricate and diverse roles of the IP6K1 protein in mammalian cell physiology. View article here: https://doi.org/10.1016/j.jbc.2024.107116
3/2/2024: Greenberg lab students Justina Thomas, Michael Adu, and Vikalp Kumar give tours of the Greenberg lab to prospective students
Shoutout to Justina, Michael (pictured), and Vikalp for giving tours of the biological sciences building and the Greenberg lab!
2/29/2024: Congratulations to our newest Ph.D., Dr. Kendall Case!
Dr. Kendall Case has successfully defended his dissertation entitled “Valproate-induced inositol depletion is a consequence of reduced MIPS expression mediated by the Henry regulatory circuit”. Dr. Case’s work has focused on elucidating the mechanism of inositol depletion by valproate, a Read More …
1/26/2024: Publication alert – our latest research article entitled “Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1)” has been accepted for publication in The Journal of Biological Chemistry!
This research, carried out primarily by Dr. Zhuqing Liang, utilized genetic and biochemical approaches to elucidate one of the mechanisms underlying decreased pyruvate dehydrogenase (PDH) activity in Tafazzin-deficient models of Barth syndrome (BTHS). This mechanism could help explain how cardiolipin Read More …
1/10/2024: Congratulations to Monica Pan for gaining admission to MIT!
Congratulations to Monica Pan on her admission to the MIT biology program! Monica, currently a high school student at Novi High School, volunteered in the Greenberg lab during the summer of 2023. Monica was mentored by Vikalp Kumar, a Greenberg Read More …
